(Benzotriazol-1-yloxy)dipiperidinocarbenium hexafluorophosphate
(Benzotriazol-1-yloxy)dipiperidinocarbenium hexafluorophosphate (CAS 190849-64-0, C17H24F6N5OP, MW 459.37) is a versatile uronium salt reagent utilized in chemical synthesis. It serves as a key reactant in peptide coupling to minimize racemization and is employed in the esterification of nucleosides for solid-phase oligonucleotide synthesis. Available from Tech Serve Solutions, this compound offers reliable performance for demanding synthetic applications.
- IUPAC
- HBPipU,O-(Benzotriazol-1-yl)-N,N,N′,N′-bis(pentamethylene)uronium hexafluorophosphate
- Synonyms
- HBPipU,O-(Benzotriazol-1-yl)-N,N,N′,N′-bis(pentamethylene)uronium hexafluorophosphate
Peptide Coupling Reagent
This compound is utilised as a coupling reagent in peptide synthesis. Its application helps to facilitate amide bond formation between amino acids while minimising the undesirable process of racemization, ensuring higher fidelity in peptide chains.
Nucleoside Esterification
It functions as a reactant for the esterification of nucleosides. This process is crucial for immobilising nucleosides onto solid phase supports, a foundational step in the automated synthesis of oligonucleotides.
Chemical Synthesis
As a synthetic reagent, it is employed in various organic transformations requiring the formation of ester or amide linkages. Its efficacy makes it suitable for complex molecule construction in research and development.
| Molecular weight | 459.37 |
|---|---|
| Empirical formula | C17H24F6N5OP |
| Assay | ≥98.0% (TLC) |
| Solubility | acetonitrile: soluble0.1 g/mL, clear |
| Storage temperature | 2-8°C |
| Application | Reactant used for: comparison of racemization during peptide coupling1 esterification of nucleosides to solid phase supports for oligonucleotide synthesis2 |
| Melting point | 206 °C (dec.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (Benzotriazol-1-yloxy)dipiperidinocarbenium hexafluorophosphate used for?
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(Benzotriazol-1-yloxy)dipiperidinocarbenium hexafluorophosphate is used as a coupling reagent in peptide synthesis to minimise racemization and for the esterification of nucleosides to solid phase supports for oligonucleotide synthesis.
What is the CAS number and formula for this compound?
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The CAS number is 190849-64-0 and the molecular formula is C17H24F6N5OP.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with an assay of ≥98.0% (TLC). We do not represent this product as USP, BP, or EP grade.
How should (Benzotriazol-1-yloxy)dipiperidinocarbenium hexafluorophosphate be handled safely?
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This compound is classified as a Warning, with hazards H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, in a well-ventilated area. Store at 2-8°C.
How is this chemical exported and shipped by TSS?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents, adhering to all necessary international shipping and export regulations.
How can I request a sample or quote?
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Please contact our sales team via the website or by phone to request a sample or a formal quotation for (Benzotriazol-1-yloxy)dipiperidinocarbenium hexafluorophosphate.
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