2-(Bromoacetyl)benzofuran
2-(Bromoacetyl)benzofuran (CAS: 23489-36-3), with the molecular formula C10H7BrO2 and a molecular weight of 239.07, is a key heterocyclic building block. It serves as a versatile reactant in organic synthesis, primarily for constructing more complex molecular architectures. Its applications span the preparation of various organic compounds, including those with potential antimicrobial and antioxidant properties.
- IUPAC
- 1-(Benzo[b]furan-2-yl)-2-bromoethan-1-one,1-(1-Benzofuran-2-yl)-2-bromoethan-1-one,1-(1-Benzofuran-2-yl)-2-bromoethanone,1-(2-Benzofuryl)-2-bromo-1-ethanone,1-(Benzofuran-2-yl)-2-bromoethanone,1-Benzo[b]furan-2-yl-2-bromoethanone,2-(2-Bromoacetyl)benzofuran,2-(Bromoacetyl)benzo[b]furan,2-Benzofuranyl bromomethyl ketone,2-Benzofuryl bromomethyl ketone
- Synonyms
- 1-(Benzo[b]furan-2-yl)-2-bromoethan-1-one1-(1-Benzofuran-2-yl)-2-bromoethan-1-one1-(1-Benzofuran-2-yl)-2-bromoethanone1-(2-Benzofuryl)-2-bromo-1-ethanone1-(Benzofuran-2-yl)-2-bromoethanone1-Benzo[b]furan-2-yl-2-bromoethanone2-(2-Bromoacetyl)benzofuran2-(Bromoacetyl)benzo[b]furan2-Benzofuranyl bromomethyl ketone2-Benzofuryl bromomethyl ketone
Eschenmoser Coupling Reactions
2-(Bromoacetyl)benzofuran is utilised as a reactant in the Eschenmoser coupling reaction, a valuable method in organic synthesis.
Preparation of β-Oxo Sulfones
It is employed in the preparation of β-oxo sulfones, which act as substrates for stereoselective Michael addition and cascade reactions.
Synthesis of Heterocyclic Compounds
This compound is a precursor for thienylpyrazole-based thiazoles and pyrazolines, investigated for antimicrobial and anti-inflammatory activities.
Antimicrobial Agent Synthesis
It is used in the preparation of isatin-(benzofuryl-thiazolyl)-hydrazones through cyclocondensation, yielding compounds with antimicrobial properties.
DNA Damage Protective Agents
2-(Bromoacetyl)benzofuran can be involved in the synthesis of 2-naphthyl ethers, which are studied for their protective effects against DNA damage.
| Molecular weight | 239.07 |
|---|---|
| Empirical formula | C10H7BrO2 |
| Assay | 97% |
| Application | Reactant for:• Eschenmoser coupling reaction1• Preparation of β-oxo sulfones as substrates for stereoselective Michael addition/cross-benzoin cascade reactions2• Preparation of thienylpyrazole-based thiazoles and pyrazolines as antimicrobial, antioxidant, anti-inflammatory, and analgesic agents3• Preparation of isatin-(benzofuryl-thiazolyl)-hydrazones by cyclocondensation with isatin-thiosemicarbazones under microwave irradiation as antimicrobial agents4• Synthesis of 2-naphthyl ethers as a protective agent against DNA damage induced by bleomycin-iron5• Asymmetric synthesis of β-dialkylamino alcohols by Ru-catalyzed transfer hydrogenation of α-dialkylamino ketones6 |
| Melting point | 86-90 °C |
Hazard statements
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Transport (UN / ADR) | UN 3261 8 / PGII |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | C |
| Risk statements (R) | 22-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-(Bromoacetyl)benzofuran used for?
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2-(Bromoacetyl)benzofuran is used as a reactant in organic synthesis, including for Eschenmoser coupling reactions, preparation of β-oxo sulfones, and synthesis of various heterocyclic compounds with potential biological activities.
What are the CAS number and formula for 2-(Bromoacetyl)benzofuran?
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The CAS number is 23489-36-3, and the empirical formula (Hill notation) is C10H7BrO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-(Bromoacetyl)benzofuran with a minimum assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeial grade unless explicitly stated.
How should 2-(Bromoacetyl)benzofuran be handled safely?
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2-(Bromoacetyl)benzofuran is classified as Danger, causing severe skin burns and eye damage (H314) and is harmful if swallowed (H302). Handle with appropriate personal protective equipment, including gloves, eye protection, and protective clothing, in a well-ventilated area. Seek immediate medical attention if exposed.
How is this chemical packed and shipped?
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This chemical is shipped according to international regulations for hazardous materials, UN 3261, Class 8, Packing Group II. Specific packaging details are available upon request.
How can I request a sample or quote?
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To request a sample or quote for 2-(Bromoacetyl)benzofuran, please contact our sales team through the website or via direct enquiry, providing your contact details and requirements.
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